Reaction Details |
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Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Ligand | BDBM50501752 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1699648 (CHEMBL4050630) |
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IC50 | 2.0±n/a nM |
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Citation | Zhang, J; Chan, A; Lippa, B; Cross, JB; Liu, C; Yin, N; Romero, JA; Lawrence, J; Heney, R; Herradura, P; Goss, J; Clark, C; Abel, C; Zhang, Y; Poutsiaka, KM; Epie, F; Conrad, M; Mahamoon, A; Nguyen, K; Chavan, A; Clark, E; Li, TC; Cheng, RK; Wood, M; Andersen, OA; Brooks, M; Kwong, J; Barker, J; Parr, IB; Gu, Y; Ryan, MD; Coleman, S; Metcalf, CA Structure-based discovery of LpxC inhibitors. Bioorg Med Chem Lett27:1670-1680 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
Type: | Enzyme |
Mol. Mass.: | 33952.00 |
Organism: | Escherichia coli |
Description: | P0A725 |
Residue: | 305 |
Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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BDBM50501752 |
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n/a |
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Name | BDBM50501752 |
Synonyms: | CHEMBL4095059 |
Type | Small organic molecule |
Emp. Form. | C26H31N3O4 |
Mol. Mass. | 449.542 |
SMILES | C[C@@H](O)[C@H](NC1CCc2cc(ccc12)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO |r| |
Structure |
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