| Reaction Details |
|---|
 | Report a problem with these data |
| Target | M-phase inducer phosphatase 2 |
|---|
| Ligand | BDBM50504275 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1814179 (CHEMBL4313753) |
|---|
| IC50 | 1390±n/a nM |
|---|
| Citation |  Jing, L; Wu, G; Hao, X; Olotu, FA; Kang, D; Chen, CH; Lee, KH; Soliman, MES; Liu, X; Song, Y; Zhan, P Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem183:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| M-phase inducer phosphatase 2 |
|---|
| Name: | M-phase inducer phosphatase 2 |
|---|
| Synonyms: | CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 64985.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 580 |
|---|
| Sequence: | MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
|
|
|
|---|
| BDBM50504275 |
|---|
| n/a |
|---|
| Name | BDBM50504275 |
|---|
| Synonyms: | CHEMBL4521092 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16ClN5O2 |
|---|
| Mol. Mass. | 393.826 |
|---|
| SMILES | Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1 |c:11| |
|---|
| Structure | 
|
|---|
Search and Browse
