| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
|---|
| Ligand | BDBM50505333 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1822500 (CHEMBL4322264) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Buchstaller, HP; Anlauf, U; Dorsch, D; Kuhn, D; Lehmann, M; Leuthner, B; Musil, D; Radtki, D; Ritzert, C; Rohdich, F; Schneider, R; Esdar, C Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity. J Med Chem62:7897-7909 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase 2 |
|---|
| Name: | Poly [ADP-ribose] polymerase 2 |
|---|
| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 66225.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UGN5 |
|---|
| Residue: | 583 |
|---|
| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
|
|
|
|---|
| BDBM50505333 |
|---|
| n/a |
|---|
| Name | BDBM50505333 |
|---|
| Synonyms: | CHEMBL4437173 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14F2N2O2 |
|---|
| Mol. Mass. | 316.3021 |
|---|
| SMILES | CC(C)(O)c1ccc(cc1)-c1nc2c(F)cc(F)cc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
