Reaction Details |
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Target | Mitogen-activated protein kinase 7 |
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Ligand | BDBM50337134 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1832017 (CHEMBL4332025) |
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IC50 | 200±n/a nM |
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Citation | Nguyen, D; Lemos, C; Wortmann, L; Eis, K; Holton, SJ; Boemer, U; Moosmayer, D; Eberspaecher, U; Weiske, J; Lechner, C; Prechtl, S; Suelzle, D; Siegel, F; Prinz, F; Lesche, R; Nicke, B; Nowak-Reppel, K; Himmel, H; Mumberg, D; von Nussbaum, F; Nising, CF; Bauser, M; Haegebarth, A Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem62:928-940 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 7 |
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Name: | Mitogen-activated protein kinase 7 |
Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 |
Type: | Protein |
Mol. Mass.: | 88377.36 |
Organism: | Homo sapiens (Human) |
Description: | Q13164 |
Residue: | 816 |
Sequence: | MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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BDBM50337134 |
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n/a |
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Name | BDBM50337134 |
Synonyms: | 2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one | CHEMBL1673046 | Scaffold, B46 | US9266890, IV-6 |
Type | Small organic molecule |
Emp. Form. | C26H30N6O3 |
Mol. Mass. | 474.5548 |
SMILES | CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCC(O)CC1 |
Structure |
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