| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 7 |
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| Ligand | BDBM50508011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1832026 (CHEMBL4332034) |
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| IC50 | 11500±n/a nM |
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| Citation |  Nguyen, D; Lemos, C; Wortmann, L; Eis, K; Holton, SJ; Boemer, U; Moosmayer, D; Eberspaecher, U; Weiske, J; Lechner, C; Prechtl, S; Suelzle, D; Siegel, F; Prinz, F; Lesche, R; Nicke, B; Nowak-Reppel, K; Himmel, H; Mumberg, D; von Nussbaum, F; Nising, CF; Bauser, M; Haegebarth, A Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem62:928-940 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 7 |
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| Name: | Mitogen-activated protein kinase 7 |
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| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 |
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| Type: | Protein |
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| Mol. Mass.: | 88377.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13164 |
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| Residue: | 816 |
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| Sequence: | MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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| BDBM50508011 |
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| n/a |
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| Name | BDBM50508011 |
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| Synonyms: | CHEMBL4455302 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N3O3 |
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| Mol. Mass. | 391.4629 |
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| SMILES | COc1cc2ncnc(C3CCN(CC3)C(=O)c3ccc(C)cc3)c2cc1OC |
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| Structure | 
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