| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50511106 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1843801 (CHEMBL4344228) |
|---|
| IC50 | 4160±n/a nM |
|---|
| Citation |  Norwood, VM; Brice-Tutt, AC; Eans, SO; Stacy, HM; Shi, G; Ratnayake, R; Rocca, JR; Abboud, KA; Li, C; Luesch, H; McLaughlin, JP; Huigens, RW Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity. J Med Chem63:5119-5138 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55808.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
|---|
| Residue: | 487 |
|---|
| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
|---|
| BDBM50511106 |
|---|
| n/a |
|---|
| Name | BDBM50511106 |
|---|
| Synonyms: | CHEMBL4527708 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29BrN2O3 |
|---|
| Mol. Mass. | 509.435 |
|---|
| SMILES | CC[C@]12CC(=O)n3c([C@@H]1OC)c(CCN(CCC2)C(=O)c1cccc(Br)c1)c1ccccc31 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
