| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 6 |
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| Ligand | BDBM50511922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1846151 (CHEMBL4346578) |
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| IC50 | 10000±n/a nM |
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| Citation |  Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Park, KS; Chau, I; Dong, A; Zeng, H; Chen, H; Meng, F; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, J; Vedadi, M; Jin, J Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J Med Chem63:5477-5487 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 6 |
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| Name: | Protein arginine N-methyltransferase 6 |
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| Synonyms: | ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6) |
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| Type: | Protein |
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| Mol. Mass.: | 41928.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 375 |
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| Sequence: | MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA
REVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKE
GGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG
LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE
SEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK
VGDQEEKTKDFAMED
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| BDBM50511922 |
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| n/a |
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| Name | BDBM50511922 |
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| Synonyms: | CHEMBL4539314 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N3O2 |
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| Mol. Mass. | 299.3675 |
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| SMILES | CN(CCO)Cc1c[nH]cc1-c1cccc(NC(=O)C=C)c1 |
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| Structure | 
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