Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50066928 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195847 (CHEMBL799146) |
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IC50 | 330±n/a nM |
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Citation | Nugent, RA; Schlachter, ST; Murphy, MJ; Cleek, GJ; Poel, TJ; Wishka, DG; Graber, DR; Yagi, Y; Keiser, BJ; Olmsted, RA; Kopta, LA; Swaney, SM; Poppe, SM; Morris, J; Tarpley, WG; Thomas, RC Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J Med Chem41:3793-803 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50066928 |
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n/a |
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Name | BDBM50066928 |
Synonyms: | 3-(4-Amino-6-chloro-pyrimidin-2-ylsulfanylmethyl)-benzoic acid methyl ester | CHEMBL125928 |
Type | Small organic molecule |
Emp. Form. | C13H12ClN3O2S |
Mol. Mass. | 309.771 |
SMILES | COC(=O)c1cccc(CSc2nc(N)cc(Cl)n2)c1 |
Structure |
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