| Reaction Details |
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 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
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| Ligand | BDBM50068322 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210069 (CHEMBL813593) |
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| IC50 | 8200.0±n/a nM |
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| Citation |  Perry, PJ; Reszka, AP; Wood, AA; Read, MA; Gowan, SM; Dosanjh, HS; Trent, JO; Jenkins, TC; Kelland, LR; Neidle, S Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. J Med Chem41:4873-84 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomerase reverse transcriptase |
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| Name: | Telomerase reverse transcriptase |
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| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127099.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1447029 |
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| Residue: | 1132 |
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| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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| BDBM50068322 |
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| n/a |
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| Name | BDBM50068322 |
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| Synonyms: | CHEMBL144219 | N-[9,10-Dioxo-8-(3-(N-methylpyrrolidin-1-yl)-propionylamino)-9,10-dihydro-anthracen-1-yl]-3-(N-methylpyrrolidin-1-yl)-propionamide; diiodide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N4O4 |
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| Mol. Mass. | 518.646 |
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| SMILES | C[N+]1(CCC(=O)Nc2cccc3C(=O)c4cccc(NC(=O)CC[N+]5(C)CCCC5)c4C(=O)c23)CCCC1 |
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| Structure | 
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