Found 50 hits with Last Name = 'dosanjh' and Initial = 'hs' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068324
(3-Dimethylamino-N-[5-(3-dimethylamino-propionylami...)Show SMILES CN(C)CCC(=O)Nc1cccc2C(=O)c3c(NC(=O)CCN(C)C)cccc3C(=O)c12 Show InChI InChI=1S/C24H28N4O4/c1-27(2)13-11-19(29)25-17-9-5-7-15-21(17)23(31)16-8-6-10-18(22(16)24(15)32)26-20(30)12-14-28(3)4/h5-10H,11-14H2,1-4H3,(H,25,29)(H,26,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50082524
(2,6-Bis(3-pyrrolidinopropionamido)anthracene-9,10-...)Show SMILES Oc1c2ccc(NC(=O)CC[NH+]3CCCC3)cc2c(O)c2ccc(NC(=O)CC[NH+]3CCCC3)cc12 Show InChI InChI=1S/C28H34N4O4/c33-25(9-15-31-11-1-2-12-31)29-19-5-7-21-23(17-19)27(35)22-8-6-20(18-24(22)28(21)36)30-26(34)10-16-32-13-3-4-14-32/h5-8,17-18,35-36H,1-4,9-16H2,(H,29,33)(H,30,34)/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068304
(CHEMBL343445 | N-[9,10-Dioxo-6-(3-pyrrolidin-1-yl-...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2C(=O)c3cc(NC(=O)CCN4CCCC4)ccc3C(=O)c2c1 Show InChI InChI=1S/C28H32N4O4/c33-25(9-15-31-11-1-2-12-31)29-19-5-7-21-23(17-19)27(35)22-8-6-20(18-24(22)28(21)36)30-26(34)10-16-32-13-3-4-14-32/h5-8,17-18H,1-4,9-16H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068320
(2,7-Bis[3-(pyrrolidino)propionamido]anthraquinone ...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2C(=O)c3ccc(NC(=O)CCN4CCCC4)cc3C(=O)c2c1 Show InChI InChI=1S/C28H32N4O4/c33-25(9-15-31-11-1-2-12-31)29-19-5-7-21-23(17-19)28(36)24-18-20(6-8-22(24)27(21)35)30-26(34)10-16-32-13-3-4-14-32/h5-8,17-18H,1-4,9-16H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068330
(CHEMBL144848 | N-[9,10-Dioxo-5-(3-piperidin-1-yl-p...)Show SMILES O=C(CCN1CCCCC1)Nc1cccc2C(=O)c3c(NC(=O)CCN4CCCCC4)cccc3C(=O)c12 Show InChI InChI=1S/C30H36N4O4/c35-25(13-19-33-15-3-1-4-16-33)31-23-11-7-9-21-27(23)29(37)22-10-8-12-24(28(22)30(21)38)32-26(36)14-20-34-17-5-2-6-18-34/h7-12H,1-6,13-20H2,(H,31,35)(H,32,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068303
(1,5-BIS[3-(DIETHYLAMINO)PROPIONAMIDO]ANTHRACENE-9,...)Show SMILES CCN(CC)CCC(=O)Nc1cccc2C(=O)c3c(NC(=O)CCN(CC)CC)cccc3C(=O)c12 Show InChI InChI=1S/C28H36N4O4/c1-5-31(6-2)17-15-23(33)29-21-13-9-11-19-25(21)27(35)20-12-10-14-22(26(20)28(19)36)30-24(34)16-18-32(7-3)8-4/h9-14H,5-8,15-18H2,1-4H3,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50080847
(3,6-Bis(3-piperidinopropionamido)acridine | 3-Pipe...)Show SMILES O=C(CCN1CCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCC4)cc3nc2c1 Show InChI InChI=1S/C29H37N5O2/c35-28(11-17-33-13-3-1-4-14-33)30-24-9-7-22-19-23-8-10-25(21-27(23)32-26(22)20-24)31-29(36)12-18-34-15-5-2-6-16-34/h7-10,19-21H,1-6,11-18H2,(H,30,35)(H,31,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068328
(CHEMBL144303 | N-[9,10-Dioxo-4-(3-(N,N-diethyl-N-m...)Show SMILES CC[N+](C)(CC)CCC(=O)Nc1ccc(NC(=O)CC[N+](C)(CC)CC)c2C(=O)c3ccccc3C(=O)c12 Show InChI InChI=1S/C30H40N4O4/c1-7-33(5,8-2)19-17-25(35)31-23-15-16-24(32-26(36)18-20-34(6,9-3)10-4)28-27(23)29(37)21-13-11-12-14-22(21)30(28)38/h11-16H,7-10,17-20H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068321
(2,7-Bis[3-(piperidino)propionamido]anthraquinone |...)Show SMILES O=C(CCN1CCCCC1)Nc1ccc2C(=O)c3ccc(NC(=O)CCN4CCCCC4)cc3C(=O)c2c1 Show InChI InChI=1S/C30H36N4O4/c35-27(11-17-33-13-3-1-4-14-33)31-21-7-9-23-25(19-21)30(38)26-20-22(8-10-24(26)29(23)37)32-28(36)12-18-34-15-5-2-6-16-34/h7-10,19-20H,1-6,11-18H2,(H,31,35)(H,32,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50080840
(3,6-Bis[3-(azepan-1-yl)propionamido]acridine | 3,6...)Show SMILES O=C(CCN1CCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCC4)cc3nc2c1 Show InChI InChI=1S/C31H41N5O2/c37-30(13-19-35-15-5-1-2-6-16-35)32-26-11-9-24-21-25-10-12-27(23-29(25)34-28(24)22-26)33-31(38)14-20-36-17-7-3-4-8-18-36/h9-12,21-23H,1-8,13-20H2,(H,32,37)(H,33,38) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50005750
(3-Diethylamino-N-[6-(3-diethylamino-propionylamino...)Show SMILES CCN(CC)CCC(=O)Nc1ccc2C(=O)c3cc(NC(=O)CCN(CC)CC)ccc3C(=O)c2c1 Show InChI InChI=1S/C28H36N4O4/c1-5-31(6-2)15-13-25(33)29-19-9-11-21-23(17-19)27(35)22-12-10-20(18-24(22)28(21)36)30-26(34)14-16-32(7-3)8-4/h9-12,17-18H,5-8,13-16H2,1-4H3,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068332
(CHEMBL144386 | N-[9,10-Dioxo-8-(3-piperidin-1-yl-p...)Show SMILES O=C(CCN1CCCCC1)Nc1cccc2C(=O)c3cccc(NC(=O)CCN4CCCCC4)c3C(=O)c12 Show InChI InChI=1S/C30H36N4O4/c35-25(13-19-33-15-3-1-4-16-33)31-23-11-7-9-21-27(23)30(38)28-22(29(21)37)10-8-12-24(28)32-26(36)14-20-34-17-5-2-6-18-34/h7-12H,1-6,13-20H2,(H,31,35)(H,32,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068311
(3-Dimethylamino-N-[6-(3-dimethylamino-propionylami...)Show SMILES CN(C)CCC(=O)Nc1ccc2C(=O)c3cc(NC(=O)CCN(C)C)ccc3C(=O)c2c1 Show InChI InChI=1S/C24H28N4O4/c1-27(2)11-9-21(29)25-15-5-7-17-19(13-15)23(31)18-8-6-16(14-20(18)24(17)32)26-22(30)10-12-28(3)4/h5-8,13-14H,9-12H2,1-4H3,(H,25,29)(H,26,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068315
(3-Diethylamino-N-[8-(3-diethylamino-propionylamino...)Show SMILES CCN(CC)CCC(=O)Nc1cccc2C(=O)c3cccc(NC(=O)CCN(CC)CC)c3C(=O)c12 Show InChI InChI=1S/C28H36N4O4/c1-5-31(6-2)17-15-23(33)29-21-13-9-11-19-25(21)28(36)26-20(27(19)35)12-10-14-22(26)30-24(34)16-18-32(7-3)8-4/h9-14H,5-8,15-18H2,1-4H3,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068312
(2,7-Bis[3-(diethylamino)propionamido]anthraquinone...)Show SMILES CCN(CC)CCC(=O)Nc1ccc2C(=O)c3ccc(NC(=O)CCN(CC)CC)cc3C(=O)c2c1 Show InChI InChI=1S/C28H36N4O4/c1-5-31(6-2)15-13-25(33)29-19-9-11-21-23(17-19)28(36)24-18-20(10-12-22(24)27(21)35)30-26(34)14-16-32(7-3)8-4/h9-12,17-18H,5-8,13-16H2,1-4H3,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068335
(CHEMBL422120 | N-[9,10-Dioxo-8-(3-(N,N,N-trimethyl...)Show SMILES C[N+](C)(C)CCC(=O)Nc1cccc2C(=O)c3cccc(NC(=O)CC[N+](C)(C)C)c3C(=O)c12 Show InChI InChI=1S/C26H32N4O4/c1-29(2,3)15-13-21(31)27-19-11-7-9-17-23(19)26(34)24-18(25(17)33)10-8-12-20(24)28-22(32)14-16-30(4,5)6/h7-12H,13-16H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50082532
(2,6-Bis(3-piperidinopropionamido)anthracene-9,10-d...)Show SMILES Oc1c2ccc(NC(=O)CC[NH+]3CCCCC3)cc2c(O)c2ccc(NC(=O)CC[NH+]3CCCCC3)cc12 Show InChI InChI=1S/C30H38N4O4/c35-27(11-17-33-13-3-1-4-14-33)31-21-7-9-23-25(19-21)29(37)24-10-8-22(20-26(24)30(23)38)32-28(36)12-18-34-15-5-2-6-16-34/h7-10,19-20,37-38H,1-6,11-18H2,(H,31,35)(H,32,36)/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50005746
(CHEMBL109382 | CHEMBL33618 | N-[9,10-Dioxo-6-(3-pi...)Show SMILES O=C(CCN1CCCCC1)Nc1ccc2C(=O)c3cc(NC(=O)CCN4CCCCC4)ccc3C(=O)c2c1 Show InChI InChI=1S/C30H36N4O4/c35-27(11-17-33-13-3-1-4-14-33)31-21-7-9-23-25(19-21)29(37)24-10-8-22(20-26(24)30(23)38)32-28(36)12-18-34-15-5-2-6-16-34/h7-10,19-20H,1-6,11-18H2,(H,31,35)(H,32,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068336
(2,7-Bis[3-(dimethylamino)propionamido]anthraquinon...)Show SMILES CN(C)CCC(=O)Nc1ccc2C(=O)c3ccc(NC(=O)CCN(C)C)cc3C(=O)c2c1 Show InChI InChI=1S/C24H28N4O4/c1-27(2)11-9-21(29)25-15-5-7-17-19(13-15)24(32)20-14-16(6-8-18(20)23(17)31)26-22(30)10-12-28(3)4/h5-8,13-14H,9-12H2,1-4H3,(H,25,29)(H,26,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068313
(CHEMBL143452 | N-[9,10-Dioxo-4-(3-(N-methylpyrroli...)Show SMILES C[N+]1(CCC(=O)Nc2ccc(NC(=O)CC[N+]3(C)CCCC3)c3C(=O)c4ccccc4C(=O)c23)CCCC1 Show InChI InChI=1S/C30H36N4O4/c1-33(15-5-6-16-33)19-13-25(35)31-23-11-12-24(32-26(36)14-20-34(2)17-7-8-18-34)28-27(23)29(37)21-9-3-4-10-22(21)30(28)38/h3-4,9-12H,5-8,13-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50080849
(3,6-Bis(3-pyrrolidinopropionamido)acridine | 3-PYR...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 Show InChI InChI=1S/C27H33N5O2/c33-26(9-15-31-11-1-2-12-31)28-22-7-5-20-17-21-6-8-23(19-25(21)30-24(20)18-22)29-27(34)10-16-32-13-3-4-14-32/h5-8,17-19H,1-4,9-16H2,(H,28,33)(H,29,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068323
(3-Dimethylamino-N-[8-(3-dimethylamino-propionylami...)Show SMILES CN(C)CCC(=O)Nc1cccc2C(=O)c3cccc(NC(=O)CCN(C)C)c3C(=O)c12 Show InChI InChI=1S/C24H28N4O4/c1-27(2)13-11-19(29)25-17-9-5-7-15-21(17)24(32)22-16(23(15)31)8-6-10-18(22)26-20(30)12-14-28(3)4/h5-10H,11-14H2,1-4H3,(H,25,29)(H,26,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50066349
(3-Trimethylammonium-N-[4-(3-dimethylammonium-propi...)Show SMILES C[N+](C)(C)CCC(=O)Nc1ccc(NC(=O)CC[N+](C)(C)C)c2C(=O)c3ccccc3C(=O)c12 Show InChI InChI=1S/C26H32N4O4/c1-29(2,3)15-13-21(31)27-19-11-12-20(28-22(32)14-16-30(4,5)6)24-23(19)25(33)17-9-7-8-10-18(17)26(24)34/h7-12H,13-16H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068318
(CHEMBL145311 | N-[9,10-Dioxo-8-(3-(N,N-diethyl-N-m...)Show SMILES CC[N+](C)(CC)CCC(=O)Nc1cccc2C(=O)c3cccc(NC(=O)CC[N+](C)(CC)CC)c3C(=O)c12 Show InChI InChI=1S/C30H40N4O4/c1-7-33(5,8-2)19-17-25(35)31-23-15-11-13-21-27(23)30(38)28-22(29(21)37)14-12-16-24(28)32-26(36)18-20-34(6,9-3)10-4/h11-16H,7-10,17-20H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068308
(CHEMBL14832 | CHEMBL90901 | N-[9,10-Dioxo-7-(3-(N-...)Show SMILES C[N+]1(CCC(=O)Nc2ccc3C(=O)c4ccc(NC(=O)CC[N+]5(C)CCCCC5)cc4C(=O)c3c2)CCCCC1 Show InChI InChI=1S/C32H40N4O4/c1-35(15-5-3-6-16-35)19-13-29(37)33-23-9-11-25-27(21-23)32(40)28-22-24(10-12-26(28)31(25)39)34-30(38)14-20-36(2)17-7-4-8-18-36/h9-12,21-22H,3-8,13-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068337
(CHEMBL343238 | N-[9,10-Dioxo-8-(3-(N-methylpiperid...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4cccc(NC(=O)CC[N+]5(C)CCCCC5)c4C(=O)c23)CCCCC1 Show InChI InChI=1S/C32H40N4O4/c1-35(17-5-3-6-18-35)21-15-27(37)33-25-13-9-11-23-29(25)32(40)30-24(31(23)39)12-10-14-26(30)34-28(38)16-22-36(2)19-7-4-8-20-36/h9-14H,3-8,15-22H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068322
(CHEMBL144219 | N-[9,10-Dioxo-8-(3-(N-methylpyrroli...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4cccc(NC(=O)CC[N+]5(C)CCCC5)c4C(=O)c23)CCCC1 Show InChI InChI=1S/C30H36N4O4/c1-33(15-3-4-16-33)19-13-25(35)31-23-11-7-9-21-27(23)30(38)28-22(29(21)37)10-8-12-24(28)32-26(36)14-20-34(2)17-5-6-18-34/h7-12H,3-6,13-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068305
(CHEMBL144334 | N-[9,10-Dioxo-5-(3-(N-methylpiperid...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4c(NC(=O)CC[N+]5(C)CCCCC5)cccc4C(=O)c23)CCCCC1 Show InChI InChI=1S/C32H40N4O4/c1-35(17-5-3-6-18-35)21-15-27(37)33-25-13-9-11-23-29(25)31(39)24-12-10-14-26(30(24)32(23)40)34-28(38)16-22-36(2)19-7-4-8-20-36/h9-14H,3-8,15-22H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068310
(CHEMBL344072 | N-[9,10-Dioxo-5-(3-(N-methylpyrroli...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4c(NC(=O)CC[N+]5(C)CCCC5)cccc4C(=O)c23)CCCC1 Show InChI InChI=1S/C30H36N4O4/c1-33(15-3-4-16-33)19-13-25(35)31-23-11-7-9-21-27(23)29(37)22-10-8-12-24(28(22)30(21)38)32-26(36)14-20-34(2)17-5-6-18-34/h7-12H,3-6,13-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068329
(CHEMBL144617 | N-[9,10-Dioxo-8-(3-(N-methylmorphol...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4cccc(NC(=O)CC[N+]5(C)CCOCC5)c4C(=O)c23)CCOCC1 Show InChI InChI=1S/C30H36N4O6/c1-33(13-17-39-18-14-33)11-9-25(35)31-23-7-3-5-21-27(23)30(38)28-22(29(21)37)6-4-8-24(28)32-26(36)10-12-34(2)15-19-40-20-16-34/h3-8H,9-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50066357
(3-(1-Methyl-piperidinium-1-yl)-N-{4-[3-(1-methyl-p...)Show SMILES C[N+]1(CCC(=O)Nc2ccc(NC(=O)CC[N+]3(C)CCCCC3)c3C(=O)c4ccccc4C(=O)c23)CCCCC1 Show InChI InChI=1S/C32H40N4O4/c1-35(17-7-3-8-18-35)21-15-27(37)33-25-13-14-26(34-28(38)16-22-36(2)19-9-4-10-20-36)30-29(25)31(39)23-11-5-6-12-24(23)32(30)40/h5-6,11-14H,3-4,7-10,15-22H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50082530
(2,6-Bis[3-(hexamethyleneimino)propionamido]anthrac...)Show SMILES Oc1c2ccc(NC(=O)CC[NH+]3CCCCCC3)cc2c(O)c2ccc(NC(=O)CC[NH+]3CCCCCC3)cc12 Show InChI InChI=1S/C32H42N4O4/c37-29(13-19-35-15-5-1-2-6-16-35)33-23-9-11-25-27(21-23)31(39)26-12-10-24(22-28(26)32(25)40)34-30(38)14-20-36-17-7-3-4-8-18-36/h9-12,21-22,39-40H,1-8,13-20H2,(H,33,37)(H,34,38)/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068326
(CHEMBL142900 | N-[9,10-Dioxo-5-(3-(N-methylmorphol...)Show SMILES C[N+]1(CCC(=O)Nc2cccc3C(=O)c4c(NC(=O)CC[N+]5(C)CCOCC5)cccc4C(=O)c23)CCOCC1 Show InChI InChI=1S/C30H36N4O6/c1-33(13-17-39-18-14-33)11-9-25(35)31-23-7-3-5-21-27(23)29(37)22-6-4-8-24(28(22)30(21)38)32-26(36)10-12-34(2)15-19-40-20-16-34/h3-8H,9-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068314
(CHEMBL145490 | N-[9,10-Dioxo-5-(3-(N,N,N-trimethyl...)Show SMILES C[N+](C)(C)CCC(=O)Nc1cccc2C(=O)c3c(NC(=O)CC[N+](C)(C)C)cccc3C(=O)c12 Show InChI InChI=1S/C26H32N4O4/c1-29(2,3)15-13-21(31)27-19-11-7-9-17-23(19)25(33)18-10-8-12-20(24(18)26(17)34)28-22(32)14-16-30(4,5)6/h7-12H,13-16H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068309
(CHEMBL144756 | CHEMBL91398 | N-[9,10-Dioxo-7-(3-(N...)Show SMILES C[N+](C)(C)CCC(=O)Nc1ccc2C(=O)c3ccc(NC(=O)CC[N+](C)(C)C)cc3C(=O)c2c1 Show InChI InChI=1S/C26H32N4O4/c1-29(2,3)13-11-23(31)27-17-7-9-19-21(15-17)26(34)22-16-18(8-10-20(22)25(19)33)28-24(32)12-14-30(4,5)6/h7-10,15-16H,11-14H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068325
(CHEMBL146602 | N-[9,10-Dioxo-7-(3-(N-methylpyrroli...)Show SMILES C[N+]1(CCC(=O)Nc2ccc3C(=O)c4ccc(NC(=O)CC[N+]5(C)CCCC5)cc4C(=O)c3c2)CCCC1 Show InChI InChI=1S/C30H36N4O4/c1-33(13-3-4-14-33)17-11-27(35)31-21-7-9-23-25(19-21)30(38)26-20-22(8-10-24(26)29(23)37)32-28(36)12-18-34(2)15-5-6-16-34/h7-10,19-20H,3-6,11-18H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068327
(CHEMBL144999 | CHEMBL92265 | N-[9,10-Dioxo-7-(3-(N...)Show SMILES C[N+]1(CCC(=O)Nc2ccc3C(=O)c4ccc(NC(=O)CC[N+]5(C)CCOCC5)cc4C(=O)c3c2)CCOCC1 Show InChI InChI=1S/C30H36N4O6/c1-33(11-15-39-16-12-33)9-7-27(35)31-21-3-5-23-25(19-21)30(38)26-20-22(4-6-24(26)29(23)37)32-28(36)8-10-34(2)13-17-40-18-14-34/h3-6,19-20H,7-18H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068307
(CHEMBL344274 | N-[9,10-Dioxo-5-(3-(N,N-diethyl-N-m...)Show SMILES CC[N+](C)(CC)CCC(=O)Nc1cccc2C(=O)c3c(NC(=O)CC[N+](C)(CC)CC)cccc3C(=O)c12 Show InChI InChI=1S/C30H40N4O4/c1-7-33(5,8-2)19-17-25(35)31-23-15-11-13-21-27(23)29(37)22-14-12-16-24(28(22)30(21)38)32-26(36)18-20-34(6,9-3)10-4/h11-16H,7-10,17-20H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50066345
(3-Trimethylammonium-N-[6-(3-dimethylammonium-propi...)Show SMILES C[N+](C)(C)CCC(=O)Nc1ccc2C(=O)c3cc(NC(=O)CC[N+](C)(C)C)ccc3C(=O)c2c1 Show InChI InChI=1S/C26H32N4O4/c1-29(2,3)13-11-23(31)27-17-7-9-19-21(15-17)25(33)20-10-8-18(16-22(20)26(19)34)28-24(32)12-14-30(4,5)6/h7-10,15-16H,11-14H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068316
(3-Diethylamino-N-[7-(3-diethylamino-propionylamino...)Show SMILES CC[N+](C)(CC)CCC(=O)Nc1ccc2C(=O)c3ccc(NC(=O)CC[N+](C)(CC)CC)cc3C(=O)c2c1 Show InChI InChI=1S/C30H40N4O4/c1-7-33(5,8-2)17-15-27(35)31-21-11-13-23-25(19-21)30(38)26-20-22(12-14-24(26)29(23)37)32-28(36)16-18-34(6,9-3)10-4/h11-14,19-20H,7-10,15-18H2,1-6H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50066350
(3-Morpholin-4-yl-N-[4-(3-morpholin-4-yl-propionyla...)Show SMILES O=C(CCN1CCOCC1)Nc1ccc(NC(=O)CCN2CCOCC2)c2C(=O)c3ccccc3C(=O)c12 Show InChI InChI=1S/C28H32N4O6/c33-23(7-9-31-11-15-37-16-12-31)29-21-5-6-22(30-24(34)8-10-32-13-17-38-18-14-32)26-25(21)27(35)19-3-1-2-4-20(19)28(26)36/h1-6H,7-18H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50066352
(3-(4-Methyl-morpholinium-4-yl)-N-{4-[3-(4-methyl-m...)Show SMILES C[N+]1(CCC(=O)Nc2ccc(NC(=O)CC[N+]3(C)CCOCC3)c3C(=O)c4ccccc4C(=O)c23)CCOCC1 Show InChI InChI=1S/C30H36N4O6/c1-33(13-17-39-18-14-33)11-9-25(35)31-23-7-8-24(32-26(36)10-12-34(2)15-19-40-20-16-34)28-27(23)29(37)21-5-3-4-6-22(21)30(28)38/h3-8H,9-20H2,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068317
(3-Morpholin-4-yl-N-[8-(3-morpholin-4-yl-propionyla...)Show SMILES O=C(CCN1CCOCC1)Nc1cccc2C(=O)c3cccc(NC(=O)CCN4CCOCC4)c3C(=O)c12 Show InChI InChI=1S/C28H32N4O6/c33-23(7-9-31-11-15-37-16-12-31)29-21-5-1-3-19-25(21)28(36)26-20(27(19)35)4-2-6-22(26)30-24(34)8-10-32-13-17-38-18-14-32/h1-6H,7-18H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50080852
(3,6-Bis[3-(heptamethyleneimino)piperizinopropionam...)Show SMILES O=C(CCN1CCCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCCC4)cc3nc2c1 Show InChI InChI=1S/C33H45N5O2/c39-32(15-21-37-17-7-3-1-4-8-18-37)34-28-13-11-26-23-27-12-14-29(25-31(27)36-30(26)24-28)35-33(40)16-22-38-19-9-5-2-6-10-20-38/h11-14,23-25H,1-10,15-22H2,(H,34,39)(H,35,40) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50082528
(2,6-Bis[3-(heptamethyleneimino)propionamido]anthra...)Show SMILES Oc1c2ccc(NC(=O)CC[NH+]3CCCCCCC3)cc2c(O)c2ccc(NC(=O)CC[NH+]3CCCCCCC3)cc12 Show InChI InChI=1S/C34H46N4O4/c39-31(15-21-37-17-7-3-1-4-8-18-37)35-25-11-13-27-29(23-25)33(41)28-14-12-26(24-30(28)34(27)42)36-32(40)16-22-38-19-9-5-2-6-10-20-38/h11-14,23-24,41-42H,1-10,15-22H2,(H,35,39)(H,36,40)/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068331
(3-Morpholin-4-yl-N-[5-(3-morpholin-4-yl-propionyla...)Show SMILES O=C(CCN1CCOCC1)Nc1cccc2C(=O)c3c(NC(=O)CCN4CCOCC4)cccc3C(=O)c12 Show InChI InChI=1S/C28H32N4O6/c33-23(7-9-31-11-15-37-16-12-31)29-21-5-1-3-19-25(21)28(36)20-4-2-6-22(26(20)27(19)35)30-24(34)8-10-32-13-17-38-18-14-32/h1-6H,7-18H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50080846
(3,6-Bis[3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octa...)Show SMILES CC12CC(CC(C)(C)C1)N(CCC(=O)Nc1ccc3cc4ccc(NC(=O)CCN5CC6(C)CC5CC(C)(C)C6)cc4nc3c1)C2 |TLB:10:9:2:5.4.8,28:29:33:36.35.39| Show InChI InChI=1S/C39H53N5O2/c1-36(2)18-30-20-38(5,22-36)24-43(30)13-11-34(45)40-28-9-7-26-15-27-8-10-29(17-33(27)42-32(26)16-28)41-35(46)12-14-44-25-39(6)21-31(44)19-37(3,4)23-39/h7-10,15-17,30-31H,11-14,18-25H2,1-6H3,(H,40,45)(H,41,46) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50005756
(3-Morpholin-4-yl-N-[6-(3-morpholin-4-yl-propionyla...)Show SMILES O=C(CCN1CCOCC1)Nc1ccc2C(=O)c3cc(NC(=O)CCN4CCOCC4)ccc3C(=O)c2c1 Show InChI InChI=1S/C28H32N4O6/c33-25(5-7-31-9-13-37-14-10-31)29-19-1-3-21-23(17-19)28(36)22-4-2-20(18-24(22)27(21)35)30-26(34)6-8-32-11-15-38-16-12-32/h1-4,17-18H,5-16H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50068340
(3-Morpholin-4-yl-N-[7-(3-morpholin-4-yl-propionyla...)Show SMILES O=C(CCN1CCOCC1)Nc1ccc2C(=O)c3ccc(NC(=O)CCN4CCOCC4)cc3C(=O)c2c1 Show InChI InChI=1S/C28H32N4O6/c33-25(5-7-31-9-13-37-14-10-31)29-19-1-3-21-23(17-19)28(36)24-18-20(2-4-22(24)27(21)35)30-26(34)6-8-32-11-15-38-16-12-32/h1-4,17-18H,5-16H2,(H,29,33)(H,30,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay. |
J Med Chem 41: 4873-84 (1998)
Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50082526
(2,6-Bis[3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octa...)Show SMILES CC12CC(CC(C)(C)C1)[N@@H+](CCC(=O)Nc1ccc3c(O)c4cc(NC(=O)CC[N@@H+]5CC6(C)CC5CC(C)(C)C6)ccc4c(O)c3c1)C2 |r,TLB:28:29:33:36.35.39,THB:10:9:2:5.4.8| Show InChI InChI=1S/C40H54N4O4/c1-37(2)17-27-19-39(5,21-37)23-43(27)13-11-33(45)41-25-7-9-29-31(15-25)35(47)30-10-8-26(16-32(30)36(29)48)42-34(46)12-14-44-24-40(6)20-28(44)18-38(3,4)22-40/h7-10,15-16,27-28,47-48H,11-14,17-24H2,1-6H3,(H,41,45)(H,42,46)/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies. |
J Med Chem 42: 4538-46 (1999)
BindingDB Entry DOI: 10.7270/Q2J103VC |
More data for this
Ligand-Target Pair | |
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