| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM12042 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1852104 (CHEMBL4352728) |
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| IC50 | 68±n/a nM |
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| Citation |  Stoye, A; Juillard, A; Tang, AH; Legac, J; Gut, J; White, KL; Charman, SA; Rosenthal, PJ; Grau, GER; Hunt, NH; Payne, RJ Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem62:5562-5578 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM12042 |
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| n/a |
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| Name | BDBM12042 |
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| Synonyms: | (2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbamoyl]-3-methylbutyl]carbamoyl}oxirane-2-carboxylic acid | E-64 | L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N5O5 |
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| Mol. Mass. | 357.4054 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#8]-[#6@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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