| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 2 |
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| Ligand | BDBM50514764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858337 (CHEMBL4359066) |
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| EC50 | 15190±n/a nM |
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| Citation |  Qiu, Y; Huang, L; Fu, J; Han, C; Fang, J; Liao, P; Chen, Z; Mo, Y; Sun, P; Liao, D; Yang, L; Wang, J; Zhang, Q; Liu, J; Liu, F; Liu, T; Huang, W; Yang, H; Jiang, R TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem63:3665-3677 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 2 |
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| Name: | Potassium channel subfamily K member 2 |
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| Synonyms: | KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1 |
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| Type: | Protein |
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| Mol. Mass.: | 47099.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95069 |
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| Residue: | 426 |
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| Sequence: | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
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| BDBM50514764 |
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| n/a |
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| Name | BDBM50514764 |
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| Synonyms: | CHEMBL4552751 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O3S |
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| Mol. Mass. | 380.46 |
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| SMILES | Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](C2)C(O)=O)cc1 |r| |
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| Structure | 
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