Reaction Details |
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Target | Cholesteryl ester transfer protein |
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Ligand | BDBM50516410 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1865111 (CHEMBL4366086) |
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IC50 | 62±n/a nM |
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Citation | Finlay, HJ; Jiang, J; Rampulla, R; Salvati, ME; Qiao, JX; Wang, TC; Lawrence, RM; Harikrishnan, LS; Kamau, MG; Taylor, DS; Chen, AYA; Yin, X; Huang, CS; Chang, M; Chen, XQ; Sleph, PG; Xu, C; Li, J; Levesque, P; Adam, LP; Wexler, RR Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor. ACS Med Chem Lett10:911-916 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholesteryl ester transfer protein |
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Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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BDBM50516410 |
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n/a |
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Name | BDBM50516410 |
Synonyms: | CHEMBL4574163 |
Type | Small organic molecule |
Emp. Form. | C30H24F12N2O4 |
Mol. Mass. | 704.5034 |
SMILES | NC(C(=O)N[C@](Cc1ccccc1)(c1ccc(F)c(OC2CC2)c1)c1cc(F)cc(OC(F)(F)C(F)F)c1)C(O)(C(F)(F)F)C(F)(F)F |r| |
Structure |
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