| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50071283 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_37378 |
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| IC50 | 2000±n/a nM |
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| Citation |  Weber, AE; Ok, HO; Alvaro, RF; Candelore, MR; Cascieri, MA; Chiu, SH; Deng, L; Forrest, MJ; Hom, GJ; Hutchins, JE; Kao, J; MacIntyre, DE; Mathvink, RJ; McLoughlin, D; Miller, RR; Newbold, RC; Olah, TV; Parmee, ER; Perkins, L; Stearns, RA; Strader, CD; Szumiloski, J; Tang, YS; Tota, L; Fisher, MH 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties. Bioorg Med Chem Lett8:2111-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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|
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| BDBM50071283 |
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| n/a |
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| Name | BDBM50071283 |
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| Synonyms: | CHEMBL67672 | N-(4-{2-[(S)-3-(6-Amino-pyridin-3-yloxy)-2-hydroxy-propylamino]-ethyl}-phenyl)-4-fluoro-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25FN4O4S |
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| Mol. Mass. | 460.522 |
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| SMILES | Nc1ccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)cn1 |
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| Structure | 
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