| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50518163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1870667 (CHEMBL4371834) |
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| IC50 | 500±n/a nM |
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| Citation |  Harcken, C; Sarko, C; Mao, C; Lord, J; Raudenbush, B; Razavi, H; Liu, P; Swinamer, A; Disalvo, D; Lee, T; Lin, S; Kukulka, A; Grbic, H; Patel, M; Patel, M; Fletcher, K; Joseph, D; White, D; Amodeo, L; Berg, K; Brown, M; Thomson, DS Discovery and optimization of pyrazole amides as antagonists of CCR1. Bioorg Med Chem Lett29:435-440 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50518163 |
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| n/a |
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| Name | BDBM50518163 |
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| Synonyms: | CHEMBL4539264 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14Cl2F3N3O |
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| Mol. Mass. | 428.235 |
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| SMILES | Cc1c(cnn1-c1ccc(Cl)c(Cl)c1)C(=O)NCc1cccc(c1)C(F)(F)F |
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| Structure | 
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