Reaction Details |
| Report a problem with these data |
Target | Prothrombin |
---|
Ligand | BDBM50072531 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_225581 (CHEMBL847937) |
---|
Ki | 75±n/a nM |
---|
Citation | St-Denis, Y; Augelli-Szafran, CE; Bachand, B; Berryman, KA; DiMaio, J; Doherty, AM; Edmunds, JJ; Leblond, L; Lévesque, S; Narasimhan, LS; Penvose-Yi, JR; Rubin, JR; Tarazi, M; Winocour, PD; Siddiqui, MA Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications. Bioorg Med Chem Lett8:3193-8 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prothrombin |
---|
Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
BDBM50072531 |
---|
n/a |
---|
Name | BDBM50072531 |
Synonyms: | (6S,8aS)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionyl]-4-oxo-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide | CHEMBL320781 |
Type | Small organic molecule |
Emp. Form. | C28H35N9O4S |
Mol. Mass. | 593.7 |
SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H]2CC[C@H](N2C(=O)C1)C(=O)NC(CCCNC(N)=N)C(=O)c1nccs1 |
Structure |
|