Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50074317

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_47004 (CHEMBL657998)

691±n/a nM

Citation

Lan, R; Liu, Q; Fan, P; Lin, S; Fernando, SR; McCallion, D; Pertwee, R; Makriyannis, A Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem42:769-76 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CNR2_MOUSE | Cannabinoid CB2 receptor | Cannabinoid receptor | Cannabinoid receptor 2 | Cnr2 | mCB2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38220.43

Organism:

MOUSE

Description:

P47936

Residue:

347

Sequence:

MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILS
SRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTAS
VGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCS
ELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLD
VRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYA
LRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT

BDBM50074317

n/a

Name

BDBM50074317

Synonyms:

1-(2,4-Dichloro-phenyl)-4-methyl-5-(2-nitro-phenyl)-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide | CHEMBL349513

Type

Small organic molecule

Emp. Form.

C22H21Cl2N5O3

Mol. Mass.

474.34

SMILES

Cc1c(nn(c1-c1ccccc1[N+]([O-])=O)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(2.64,-7.18,;3.6,-8.38,;5.14,-8.34,;5.68,-9.78,;4.46,-10.72,;3.18,-9.88,;1.73,-10.4,;1.49,-11.91,;.04,-12.44,;-1.14,-11.46,;-.89,-9.94,;.56,-9.41,;-.22,-8.08,;-.25,-6.33,;-1.79,-8.09,;4.52,-12.26,;3.22,-13.09,;3.27,-14.6,;4.63,-15.34,;4.68,-16.88,;5.93,-14.53,;5.88,-12.99,;7.18,-12.17,;6,-7.06,;5.3,-5.68,;7.54,-7.16,;8.38,-5.88,;7.71,-4.5,;8.57,-3.22,;10.11,-3.34,;10.78,-4.73,;9.92,-6,)|

Structure