| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50520460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1880241 (CHEMBL4381635) |
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| IC50 | 16±n/a nM |
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| Citation |  Peng, YH; Liao, FY; Tseng, CT; Kuppusamy, R; Li, AS; Chen, CH; Fan, YS; Wang, SY; Wu, MH; Hsueh, CC; Chang, JY; Lee, LC; Shih, C; Shia, KS; Yeh, TK; Hung, MS; Kuo, CC; Song, JS; Wu, SY; Ueng, SH Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. J Med Chem63:1642-1659 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50520460 |
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| n/a |
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| Name | BDBM50520460 |
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| Synonyms: | CHEMBL4549501 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N5S2 |
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| Mol. Mass. | 377.486 |
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| SMILES | S=C(NCc1cnc2scc(C#CC3CC3)n12)Nc1ccc(cc1)C#N |
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| Structure | 
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