Reaction Details |
| Report a problem with these data |
Target | Polyunsaturated fatty acid 5-lipoxygenase |
---|
Ligand | BDBM50076649 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_4160 (CHEMBL619227) |
---|
IC50 | 10±n/a nM |
---|
Citation | Connolly, PJ; Wetter, SK; Beers, KN; Hamel, SC; Chen, RH; Wachter, MP; Ansell, J; Singer, MM; Steber, M; Ritchie, DM; Argentieri, DC N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase. Bioorg Med Chem Lett9:979-84 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyunsaturated fatty acid 5-lipoxygenase |
---|
Name: | Polyunsaturated fatty acid 5-lipoxygenase |
Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
Type: | PROTEIN |
Mol. Mass.: | 78082.31 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1432947 |
Residue: | 673 |
Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
|
|
|
BDBM50076649 |
---|
n/a |
---|
Name | BDBM50076649 |
Synonyms: | CHEMBL369848 | N-{1-methyl-3-[1-(4-methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]prop-2-ynyl}-N-hydroxyurea |
Type | Small organic molecule |
Emp. Form. | C21H19ClN4O3 |
Mol. Mass. | 410.854 |
SMILES | COc1ccc(cc1)-n1nc(cc1-c1ccc(Cl)cc1)C#CC(C)N(O)C(N)=O |
Structure |
|