| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM50521763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1885222 (CHEMBL4386804) |
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| EC50 | 8.0±n/a nM |
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| Citation |  Chopko, TC; Han, C; Gregro, AR; Engers, DW; Felts, AS; Poslusney, MS; Bollinger, KA; Morrison, RD; Bubser, M; Lamsal, A; Luscombe, VB; Cho, HP; Schnetz-Boutaud, NC; Rodriguez, AL; Chang, S; Daniels, JS; Stec, DF; Niswender, CM; Jones, CK; Wood, MR; Wood, MW; Duggan, ME; Brandon, NJ; Conn, PJ; Bridges, TM; Lindsley, CW; Melancon, BJ SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M Bioorg Med Chem Lett29:2224-2228 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM50521763 |
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| n/a |
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| Name | BDBM50521763 |
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| Synonyms: | CHEMBL4579086 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18ClN5OS |
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| Mol. Mass. | 411.908 |
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| SMILES | Cc1nnc2c(Cl)c(C)c3c(N)c(sc3n12)C(=O)NC1Cc2ccccc2C1 |
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| Structure | 
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