| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM151238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1888464 (CHEMBL4390141) |
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| IC50 | 190±n/a nM |
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| Citation |  Kim, SH; Johnson, JA; Jiang, J; Parkhurst, B; Phillips, M; Pi, Z; Qiao, JX; Tora, G; Ye Chen, A; Liu, E; Yin, X; Yang, R; Zhao, L; Taylor, DS; Basso, M; Behnia, K; Onorato, J; Chen, XQ; Abell, LM; Lu, H; Locke, G; Caporuscio, C; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase. Bioorg Med Chem Lett29:1918-1921 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg |
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| Type: | Protein |
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| Mol. Mass.: | 56643.58 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9WVG5 |
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| Residue: | 500 |
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| Sequence: | MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPE
QEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHID
IYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
SRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNN
SGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVA
HSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWF
HKCQDGWKMKNKTSPFVNLA
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| BDBM151238 |
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| n/a |
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| Name | BDBM151238 |
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| Synonyms: | US8987314, B34 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N6O6S3 |
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| Mol. Mass. | 556.679 |
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| SMILES | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cnn(CCN2CCOCC2)c1 |
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| Structure | 
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