| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, endothelial |
|---|
| Ligand | BDBM50523391 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1890185 (CHEMBL4391939) |
|---|
| IC50 | 26000±n/a nM |
|---|
| Citation |  Chalupova, K; Korabecny, J; Bartolini, M; Monti, B; Lamba, D; Caliandro, R; Pesaresi, A; Brazzolotto, X; Gastellier, AJ; Nachon, F; Pejchal, J; Jarosova, M; Hepnarova, V; Jun, D; Hrabinova, M; Dolezal, R; Zdarova Karasova, J; Mzik, M; Kristofikova, Z; Misik, J; Muckova, L; Jost, P; Soukup, O; Benkova, M; Setnicka, V; Habartova, L; Chvojkova, M; Kleteckova, L; Vales, K; Mezeiova, E; Uliassi, E; Valis, M; Nepovimova, E; Bolognesi, ML; Kuca, K Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Eur J Med Chem168:491-514 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, endothelial |
|---|
| Name: | Nitric oxide synthase, endothelial |
|---|
| Synonyms: | Constitutive NOS | EC-NOS | Endothelial NOS | NOS type III | NOS3_RAT | NOSIII | Nos3 | cNOS | eNOS |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 133297.24 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_812454 |
|---|
| Residue: | 1202 |
|---|
| Sequence: | MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTR
PPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTE
QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAESLQLLPRLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP
GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETP
GS
|
|
|
|---|
| BDBM50523391 |
|---|
| n/a |
|---|
| Name | BDBM50523391 |
|---|
| Synonyms: | CHEMBL4449083 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H38Cl3N5O |
|---|
| Mol. Mass. | 591.015 |
|---|
| SMILES | Cl.Cl.N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCNc1c2CCCCc2nc2cc(Cl)ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
