Ki Summary

Reaction Details

Report a problem with these data

Target

Nuclear receptor subfamily 4 group A member 1

Ligand

BDBM50071058

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1894491 (CHEMBL4396412)

290±n/a nM

Citation

Chen, Z; Zhang, D; Yan, S; Hu, C; Huang, Z; Li, Z; Peng, S; Li, X; Zhu, Y; Yu, H; Lian, B; Kang, Q; Li, M; Zeng, Z; Zhang, XK; Su, Y SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem177:171-187 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nuclear receptor subfamily 4 group A member 1

Name:

Nuclear receptor subfamily 4 group A member 1

Synonyms:

GFRP1 | HMR | NAK1 | NR4A1 | NR4A1_HUMAN | nuclear receptor subfamily 4, group A, member 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64467.13

Organism:

Homo sapiens (Human)

Description:

gi_27894344

Residue:

598

Sequence:

MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

BDBM50071058

n/a

Name

BDBM50071058

Synonyms:

(2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid | CELASTROL | CHEMBL301982 | cid_4274774

Type

Small organic molecule

Emp. Form.

C29H38O4

Mol. Mass.

450.6096

SMILES

C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17|

Structure