| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase CSK |
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| Ligand | BDBM50083644 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_52345 |
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| IC50 | >10000±n/a nM |
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| Citation |  Moffat, D; Davis, P; Hutchings, M; Davis, J; Berg, D; Batchelor, M; Johnson, J; O'Connell, J; Martin, R; Crabbe, T; Delgado, J; Perry, M 4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70. Bioorg Med Chem Lett9:3351-6 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase CSK |
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| Name: | Tyrosine-protein kinase CSK |
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| Synonyms: | C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 50707.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41240 |
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| Residue: | 450 |
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| Sequence: | MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
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| BDBM50083644 |
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| n/a |
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| Name | BDBM50083644 |
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| Synonyms: | CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-pyrimidin-2-yl]-(3,4,5-trimethoxy-phenyl)-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N6O3 |
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| Mol. Mass. | 422.4802 |
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| SMILES | COc1cc(Nc2nccc(n2)-c2ccc(nc2)N2CCNCC2)cc(OC)c1OC |
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| Structure | 
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