Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Short transient receptor potential channel 5 | ||
| Ligand | BDBM50529447 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1908620 (CHEMBL4410978) | ||
| IC50 | 530±n/a nM | ||
| Citation |  Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett10:1579-1585 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Short transient receptor potential channel 5 | |||
| Name: | Short transient receptor potential channel 5 | ||
| Synonyms: | TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 111421.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9UL62 | ||
| Residue: | 973 | ||
| Sequence: |
| ||
| BDBM50529447 | |||
| n/a | |||
| Name | BDBM50529447 | ||
| Synonyms: | CHEMBL4517031 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H23ClN4O2 | ||
| Mol. Mass. | 338.832 | ||
| SMILES | C[C@H]1CC[C@H](CN2CCN(CC2=O)c2cn[nH]c(=O)c2Cl)CC1 |r,wU:4.4,wD:1.0,(47.27,-39.08,;48.6,-38.32,;49.94,-39.1,;51.28,-38.34,;51.28,-36.8,;52.62,-36.04,;53.95,-36.83,;53.93,-38.37,;55.27,-39.16,;56.6,-38.39,;56.61,-36.85,;55.29,-36.07,;55.3,-34.53,;57.93,-39.17,;59.26,-38.4,;60.6,-39.16,;60.6,-40.71,;59.27,-41.48,;59.26,-43.02,;57.93,-40.71,;56.6,-41.48,;49.96,-36.02,;48.62,-36.78,)| | ||
| Structure | 
| ||