| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Short transient receptor potential channel 5 |
|---|
| Ligand | BDBM50529452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1908620 (CHEMBL4410978) |
|---|
| IC50 | 1500±n/a nM |
|---|
| Citation |  Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett10:1579-1585 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Short transient receptor potential channel 5 |
|---|
| Name: | Short transient receptor potential channel 5 |
|---|
| Synonyms: | TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 111421.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UL62 |
|---|
| Residue: | 973 |
|---|
| Sequence: | MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
WGDGQEEQVTTRL
|
|
|
|---|
| BDBM50529452 |
|---|
| n/a |
|---|
| Name | BDBM50529452 |
|---|
| Synonyms: | CHEMBL4458885 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22N4O2 |
|---|
| Mol. Mass. | 338.4036 |
|---|
| SMILES | Cc1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
