Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM50437406 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1923496 (CHEMBL4426452) |
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IC50 | 0.200000±n/a nM |
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Citation | Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers. J Med Chem59:6501-11 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK-2 | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | MAP kinase 2 | MAPK 2 | MK01_RAT | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42-MAPK |
Type: | Enzyme |
Mol. Mass.: | 41278.65 |
Organism: | Rattus norvegicus (rat) |
Description: | MAP Kinase is the rat ERK-2 isoform containing a polyhistidine tag at the N-terminus produced in
E.coli. and activated by phosphorylation with MEK1 prior to purification. |
Residue: | 358 |
Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50437406 |
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n/a |
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Name | BDBM50437406 |
Synonyms: | CHEMBL2408788 | US9023865, 9 |
Type | Small organic molecule |
Emp. Form. | C20H18N6O |
Mol. Mass. | 358.3965 |
SMILES | Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccccc3)ncc12 |
Structure |
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