| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
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| Ligand | BDBM50536654 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1933876 (CHEMBL4479528) |
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| IC50 | 1514±n/a nM |
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| Citation |  Temple, KJ; Duvernay, MT; Young, SE; Wen, W; Wu, W; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against ?-Thrombin. J Med Chem59:7690-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 4 |
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| Name: | Proteinase-activated receptor 4 |
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| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
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| Type: | Protein |
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| Mol. Mass.: | 41145.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI0 |
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| Residue: | 385 |
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| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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| BDBM50536654 |
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| n/a |
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| Name | BDBM50536654 |
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| Synonyms: | CHEMBL4570494 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClF3N3O3 |
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| Mol. Mass. | 463.837 |
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| SMILES | COc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 |
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| Structure | 
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