Compile Data Set for Download or QSAR

Found 78 hits with Last Name = 'young' and Initial = 'se'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets after 10 mins by flow cytometric analysis				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50536645 (CHEMBL4528799) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-8-15(31-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins using dextromethorphan substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins using dextromethorphan substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024254 (CHEMBL125021) Show SMILES CCOC(=O)c1ccc(cc1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C23H20N2O2/c1-2-27-23(26)19-14-12-18(13-15-19)22-20-10-6-7-11-21(20)25(24-22)16-17-8-4-3-5-9-17/h3-15H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity PAR4 (unknown origin)				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024254 (CHEMBL125021) Show SMILES CCOC(=O)c1ccc(cc1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C23H20N2O2/c1-2-27-23(26)19-14-12-18(13-15-19)22-20-10-6-7-11-21(20)25(24-22)16-17-8-4-3-5-9-17/h3-15H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536642 (CHEMBL4566669) Show SMILES COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16ClF3N4O3S/c1-32-21-28-30-10-16(27-20(30)34-21)19-14-8-13(33-22(24,25)26)6-7-17(14)29(18(19)11-31)9-12-4-2-3-5-15(12)23/h2-8,10,31H,9,11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in in human platelets assessed as inhibition of P-selectin activation				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024252 (CHEMBL1609104) Show SMILES Cn1c(CO)c(-c2ccccc2)c2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536642 (CHEMBL4566669) Show SMILES COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16ClF3N4O3S/c1-32-21-28-30-10-16(27-20(30)34-21)19-14-8-13(33-22(24,25)26)6-7-17(14)29(18(19)11-31)9-12-4-2-3-5-15(12)23/h2-8,10,31H,9,11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536642 (CHEMBL4566669) Show SMILES COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16ClF3N4O3S/c1-32-21-28-30-10-16(27-20(30)34-21)19-14-8-13(33-22(24,25)26)6-7-17(14)29(18(19)11-31)9-12-4-2-3-5-15(12)23/h2-8,10,31H,9,11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536657 (CHEMBL4586027) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-7-6-15(31-22(24,25)26)8-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	204	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536657 (CHEMBL4586027) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-7-6-15(31-22(24,25)26)8-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024255 (CHEMBL3334944) Show SMILES CCCNCc1c(-c2ccccc2)c2cc(ccc2n1C)[N+]([O-])=O Show InChI InChI=1S/C19H21N3O2/c1-3-11-20-13-18-19(14-7-5-4-6-8-14)16-12-15(22(23)24)9-10-17(16)21(18)2/h4-10,12,20H,3,11,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	279	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024258 (CHEMBL3334941) Show SMILES Cn1c(COCc2ccccc2)c(-c2ccccc2)c2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C23H20N2O3/c1-24-21-13-12-19(25(26)27)14-20(21)23(18-10-6-3-7-11-18)22(24)16-28-15-17-8-4-2-5-9-17/h2-14H,15-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	435	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in in human platelets assessed as inhibition of P-selectin activation				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536645 (CHEMBL4528799) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-8-15(31-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536645 (CHEMBL4528799) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-8-15(31-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024259 (CHEMBL3334940) Show SMILES CCCOCc1c(-c2ccccc2)c2cc(ccc2n1C)[N+]([O-])=O Show InChI InChI=1S/C19H20N2O3/c1-3-11-24-13-18-19(14-7-5-4-6-8-14)16-12-15(21(22)23)9-10-17(16)20(18)2/h4-10,12H,3,11,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	646	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024260 (CHEMBL3334939) Show SMILES COCc1c(-c2ccccc2)c2cc(ccc2n1C)[N+]([O-])=O Show InChI InChI=1S/C17H16N2O3/c1-18-15-9-8-13(19(20)21)10-14(15)17(16(18)11-22-2)12-6-4-3-5-7-12/h3-10H,11H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	785	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024257 (CHEMBL3334942) Show SMILES CNCc1c(-c2ccccc2)c2cc(ccc2n1C)[N+]([O-])=O Show InChI InChI=1S/C17H17N3O2/c1-18-11-16-17(12-6-4-3-5-7-12)14-10-13(20(21)22)8-9-15(14)19(16)2/h3-10,18H,11H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	793	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536659 (CHEMBL4517009) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-8-7-16(32-23(25,26)27)10-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	813	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536659 (CHEMBL4517009) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-8-7-16(32-23(25,26)27)10-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50536642 (CHEMBL4566669) Show SMILES COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16ClF3N4O3S/c1-32-21-28-30-10-16(27-20(30)34-21)19-14-8-13(33-22(24,25)26)6-7-17(14)29(18(19)11-31)9-12-4-2-3-5-15(12)23/h2-8,10,31H,9,11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins using dextromethorphan substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536643 (CHEMBL4567147) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccc(F)cc2F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16F5N3O2S/c1-33-21-28-8-13(9-29-21)20-16-7-15(32-22(25,26)27)4-5-18(16)30(19(20)11-31)10-12-2-3-14(23)6-17(12)24/h2-9,31H,10-11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536643 (CHEMBL4567147) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccc(F)cc2F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16F5N3O2S/c1-33-21-28-8-13(9-29-21)20-16-7-15(32-22(25,26)27)4-5-18(16)30(19(20)11-31)10-12-2-3-14(23)6-17(12)24/h2-9,31H,10-11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536644 (CHEMBL4537098) Show SMILES COc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1ccc(OC)nc1 Show InChI InChI=1S/C23H21ClN2O3/c1-28-17-8-9-18-20(11-17)26(13-16-5-3-4-6-19(16)24)21(14-27)23(18)15-7-10-22(29-2)25-12-15/h3-12,27H,13-14H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536644 (CHEMBL4537098) Show SMILES COc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1ccc(OC)nc1 Show InChI InChI=1S/C23H21ClN2O3/c1-28-17-8-9-18-20(11-17)26(13-16-5-3-4-6-19(16)24)21(14-27)23(18)15-7-10-22(29-2)25-12-15/h3-12,27H,13-14H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536654 (CHEMBL4570494) Show SMILES COc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O3/c1-31-21-27-9-14(10-28-21)20-16-8-15(32-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536654 (CHEMBL4570494) Show SMILES COc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O3/c1-31-21-27-9-14(10-28-21)20-16-8-15(32-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536663 (CHEMBL4483019) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2cccc(Br)c2)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18BrF3N2O3/c1-31-21-8-5-15(11-28-21)22-18-10-17(32-23(25,26)27)6-7-19(18)29(20(22)13-30)12-14-3-2-4-16(24)9-14/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536663 (CHEMBL4483019) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2cccc(Br)c2)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18BrF3N2O3/c1-31-21-8-5-15(11-28-21)22-18-10-17(32-23(25,26)27)6-7-19(18)29(20(22)13-30)12-14-3-2-4-16(24)9-14/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50536645 (CHEMBL4528799) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-8-15(31-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins using phenacetin substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536656 (CHEMBL4571068) Show SMILES CCOc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H23ClN2O3/c1-3-30-18-9-10-19-21(12-18)27(14-17-6-4-5-7-20(17)25)22(15-28)24(19)16-8-11-23(29-2)26-13-16/h4-13,28H,3,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536656 (CHEMBL4571068) Show SMILES CCOc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H23ClN2O3/c1-3-30-18-9-10-19-21(12-18)27(14-17-6-4-5-7-20(17)25)22(15-28)24(19)16-8-11-23(29-2)26-13-16/h4-13,28H,3,14-15H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536661 (CHEMBL4516569) Show SMILES COc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1cnc(SC)nc1 Show InChI InChI=1S/C22H20ClN3O2S/c1-28-16-7-8-17-19(9-16)26(12-14-5-3-4-6-18(14)23)20(13-27)21(17)15-10-24-22(29-2)25-11-15/h3-11,27H,12-13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536661 (CHEMBL4516569) Show SMILES COc1ccc2c(c(CO)n(Cc3ccccc3Cl)c2c1)-c1cnc(SC)nc1 Show InChI InChI=1S/C22H20ClN3O2S/c1-28-16-7-8-17-19(9-16)26(12-14-5-3-4-6-18(14)23)20(13-27)21(17)15-10-24-22(29-2)25-11-15/h3-11,27H,12-13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins using phenacetin substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536642 (CHEMBL4566669) Show SMILES COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H16ClF3N4O3S/c1-32-21-28-30-10-16(27-20(30)34-21)19-14-8-13(33-22(24,25)26)6-7-17(14)29(18(19)11-31)9-12-4-2-3-5-15(12)23/h2-8,10,31H,9,11H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced PAC1 binding response preincubated for 20 mins followed b...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536650 (CHEMBL4544189) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2cccc(c2)C(F)(F)F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C24H18F6N2O3/c1-34-21-8-5-15(11-31-21)22-18-10-17(35-24(28,29)30)6-7-19(18)32(20(22)13-33)12-14-3-2-4-16(9-14)23(25,26)27/h2-11,33H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.79E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536650 (CHEMBL4544189) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2cccc(c2)C(F)(F)F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C24H18F6N2O3/c1-34-21-8-5-15(11-31-21)22-18-10-17(35-24(28,29)30)6-7-19(18)32(20(22)13-33)12-14-3-2-4-16(9-14)23(25,26)27/h2-11,33H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536660 (CHEMBL4514069) Show SMILES CCOc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H19ClF3N3O3/c1-2-32-22-28-10-15(11-29-22)21-17-9-16(33-23(25,26)27)7-8-19(17)30(20(21)13-31)12-14-5-3-4-6-18(14)24/h3-11,31H,2,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536660 (CHEMBL4514069) Show SMILES CCOc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H19ClF3N3O3/c1-2-32-22-28-10-15(11-29-22)21-17-9-16(33-23(25,26)27)7-8-19(17)30(20(21)13-31)12-14-5-3-4-6-18(14)24/h3-11,31H,2,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536641 (CHEMBL4514977) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccc(F)cc2F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H17F5N2O3/c1-32-21-7-3-13(10-29-21)22-17-9-16(33-23(26,27)28)5-6-19(17)30(20(22)12-31)11-14-2-4-15(24)8-18(14)25/h2-10,31H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536641 (CHEMBL4514977) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccc(F)cc2F)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H17F5N2O3/c1-32-21-7-3-13(10-29-21)22-17-9-16(33-23(26,27)28)5-6-19(17)30(20(22)12-31)11-14-2-4-15(24)8-18(14)25/h2-10,31H,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50024256 (CHEMBL3334943) Show SMILES COCCOCc1c(-c2ccccc2)c2cc(ccc2n1C)[N+]([O-])=O Show InChI InChI=1S/C19H20N2O4/c1-20-17-9-8-15(21(22)23)12-16(17)19(14-6-4-3-5-7-14)18(20)13-25-11-10-24-2/h3-9,12H,10-11,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50536645 (CHEMBL4528799) Show SMILES CSc1ncc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C22H17ClF3N3O2S/c1-32-21-27-9-14(10-28-21)20-16-8-15(31-22(24,25)26)6-7-18(16)29(19(20)12-30)11-13-4-2-3-5-17(13)23/h2-10,30H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes incubated for 15 mins using diclofenac substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes incubated for 15 mins using diclofenac substrate in presence of NADPH by LC-MS/MS method				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM50536646 (CHEMBL4557930) Show SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12 Show InChI InChI=1S/C23H18ClF3N2O3/c1-31-21-9-6-14(11-28-21)22-17-10-16(32-23(25,26)27)7-8-19(17)29(20(22)13-30)12-15-4-2-3-5-18(15)24/h2-11,30H,12-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced PAC1 binding response preincubated for 20 mins followed b...				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928 BindingDB Entry DOI: 10.7270/Q29C71XC
					More data for this Ligand-Target Pair

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