| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 1 |
|---|
| Ligand | BDBM50539668 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1978551 (CHEMBL4611686) |
|---|
| EC50 | 3600±n/a nM |
|---|
| Citation |  Davidsson, Ö; Nilsson, K; Brånalt, J; Andersson, T; Berggren, K; Chen, Y; Fjellström, O; Gradén, H; Gustafsson, L; Hermansson, NO; Jansen, F; Johannesson, P; Ohlsson, B; Tyrchan, C; Wellner, A; Wellner, E; Ölwegård-Halvarsson, M Identification of novel GPR81 agonist lead series for target biology evaluation. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 1 |
|---|
| Name: | Hydroxycarboxylic acid receptor 1 |
|---|
| Synonyms: | G-protein coupled receptor 104 | GPR104 | GPR81 | HCA1 | HCAR1 | HCAR1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 39313.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_850283 |
|---|
| Residue: | 346 |
|---|
| Sequence: | MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVA
DFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHP
HHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIM
FQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSAR
LYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPK
QPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
|
|
|
|---|
| BDBM50539668 |
|---|
| n/a |
|---|
| Name | BDBM50539668 |
|---|
| Synonyms: | CHEMBL4637505 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22ClFN6O4S2 |
|---|
| Mol. Mass. | 577.051 |
|---|
| SMILES | CN1CCC(CC1)S(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(c(F)cc3Cl)-n3cccn3)sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
