| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesterol 24-hydroxylase |
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| Ligand | BDBM50097575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1980733 (CHEMBL4613995) |
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| Kd | 3300±n/a nM |
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| Citation |  Mast, N; Verwilst, P; Wilkey, CJ; Guengerich, FP; Pikuleva, IA In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. J Med Chem63:6477-6488 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesterol 24-hydroxylase |
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| Name: | Cholesterol 24-hydroxylase |
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| Synonyms: | CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H) |
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| Type: | Protein |
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| Mol. Mass.: | 56834.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6A2 |
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| Residue: | 500 |
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| Sequence: | MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
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| BDBM50097575 |
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| n/a |
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| Name | BDBM50097575 |
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| Synonyms: | 6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one | CHEMBL346356 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9ClF3NO3 |
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| Mol. Mass. | 331.674 |
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| SMILES | Oc1cc2NC(=O)OC(C#CC3CC3)(c2cc1Cl)C(F)(F)F |
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| Structure | 
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