Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50545375 (CHEMBL4527162) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity to full length human CYP46A1 expressed in Escherichia coli DH5alpha as cholesterol-24 hydroxylation using cholesterol as substrate i... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127068 BindingDB Entry DOI: 10.7270/Q2PK0KRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM31774 (CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31774 (CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31774 (CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM31772 (1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31772 (1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31772 (1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM8610 (1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.34E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM8610 (1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.71E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM8610 (1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM25817 (2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.31E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM25817 (2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 8.60E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM50333117 ((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | n/a | 1.74E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM50127138 (2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.02E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM24656 (4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.80E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM24656 (4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.16E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM24656 (4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM92505 (4-Cholesten-3-one | Steroid scaffold, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM92505 (4-Cholesten-3-one | Steroid scaffold, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM20192 ((1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM20192 ((1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097571 ((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097575 (6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540104 (CHEMBL4636944) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540106 (CHEMBL3344478) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540107 (CHEMBL4639106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 2.58E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540108 (CHEMBL4632958) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540109 (CHEMBL3344474) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540110 (CHEMBL4645070) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097571 ((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097575 (6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540108 (CHEMBL4632958) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540109 (CHEMBL3344474) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540110 (CHEMBL4645070) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair |