Reaction Details |
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Target | Cholesterol 24-hydroxylase |
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Ligand | BDBM50540104 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1980733 (CHEMBL4613995) |
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Kd | 3200±n/a nM |
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Citation | Mast, N; Verwilst, P; Wilkey, CJ; Guengerich, FP; Pikuleva, IA In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. J Med Chem63:6477-6488 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholesterol 24-hydroxylase |
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Name: | Cholesterol 24-hydroxylase |
Synonyms: | CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H) |
Type: | Protein |
Mol. Mass.: | 56834.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y6A2 |
Residue: | 500 |
Sequence: | MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
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BDBM50540104 |
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n/a |
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Name | BDBM50540104 |
Synonyms: | CHEMBL4636944 |
Type | Small organic molecule |
Emp. Form. | C15H10ClF3O2 |
Mol. Mass. | 314.687 |
SMILES | FC(F)(F)C1(OC(=O)Cc2ccc(Cl)cc12)C#CC1CC1 |
Structure |
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