| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent Clp protease ATP-binding subunit ClpC1 |
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| Ligand | BDBM50540277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1981275 (CHEMBL4614537) |
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| Kd | 310±n/a nM |
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| Citation |  Zhou, B; Shetye, G; Yu, Y; Santarsiero, BD; Klein, LL; Abad-Zapatero, C; Wolf, NM; Cheng, J; Jin, Y; Lee, H; Suh, JW; Lee, H; Bisson, J; McAlpine, JB; Chen, SN; Cho, SH; Franzblau, SG; Pauli, GF Antimycobacterial Rufomycin Analogues from J Nat Prod83:657-667 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent Clp protease ATP-binding subunit ClpC1 |
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| Name: | ATP-dependent Clp protease ATP-binding subunit ClpC1 |
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| Synonyms: | CLPC1_MYCTU | Caseinolytic protein C1 (ClpC1) | clpC1 |
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| Type: | Protein |
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| Mol. Mass.: | 93541.69 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WPC9 |
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| Residue: | 848 |
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| Sequence: | MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVR
SQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVA
AQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTA
AAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG
AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILK
GLRDRYEAHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPD
LREFDEKIAEARREKESAIDAQDFEKAASLRDREKTLVAQRAEREKQWRSGDLDVVAEVD
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLK
DPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG
YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNT
VLIFTSNLGTSDISKPVGLGFSKGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
QLTREEIIRMVDLMISRVAGQLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQRE
IEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSA
GGPEPAAR
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| BDBM50540277 |
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| n/a |
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| Name | BDBM50540277 |
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| Synonyms: | CHEMBL4649342 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H81N9O13 |
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| Mol. Mass. | 1088.2948 |
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| SMILES | COC(OC)C(C)C[C@@H]1N(C)C(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)c(c2)[N+]([O-])=O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc2cn(c3ccccc23)C(C)(C)[C@H]2CO2)NC(=O)[C@H](C\C=C\C)NC(=O)[C@H](CC(C)C)NC1=O |r| |
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| Structure | 
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