| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50545898 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2013168 (CHEMBL4666746) |
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| EC50 | >10000±n/a nM |
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| Citation |  Shinozuka, T; Tsukada, T; Fujii, K; Tokumaru, E; Matsui, Y; Wakimoto, S; Ogata, T; Araki, K; Sawamura, R; Watanabe, N; Mori, M; Tanaka, J Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930. ACS Med Chem Lett10:358-362 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50545898 |
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| n/a |
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| Name | BDBM50545898 |
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| Synonyms: | CHEMBL4752897 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N3O6 |
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| Mol. Mass. | 449.4559 |
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| SMILES | CCOc1cc(Oc2ccnc(OC)c2)cc2n(C)c(COc3cccc(c3)C(O)=O)nc12 |
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| Structure | 
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