| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM50546403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2015641 (CHEMBL4669219) |
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| IC50 | 0.480000±n/a nM |
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| Citation |  Kawatkar, SP; Barlaam, B; Kemmitt, P; Simpson, I; Watson, D; Wang, P; Lamont, S; Su, Q; Boiko, S; Ikeda, T; Patel, J; Pike, A; Pollard, H; Read, J; Sarkar, U; Wang, H; Wen, Q; Yan, Z; Dowling, JE; Dry, H; Edmondson, SD Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM50546403 |
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| n/a |
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| Name | BDBM50546403 |
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| Synonyms: | CHEMBL4779316 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N7O |
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| Mol. Mass. | 413.475 |
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| SMILES | Cn1ccc2c(cccc12)-c1nc2c(ccnc2[nH]1)-n1cc(CN2CC[C@@H](O)C2)cn1 |r| |
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| Structure | 
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