Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 9

Ligand

BDBM50105742

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_91768

IC50

5±n/a nM

Citation

Adams, JL; Boehm, JC; Gallagher, TF; Kassis, S; Webb, EF; Hall, R; Sorenson, M; Garigipati, R; Griswold, DE; Lee, JC Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. Bioorg Med Chem Lett11:2867-70 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 9

Name:

Mitogen-activated protein kinase 9

Synonyms:

Type:

Enzyme

Mol. Mass.:

48131.49

Organism:

Homo sapiens (Human)

Description:

JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).

Residue:

424

Sequence:

MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR

BDBM50105742

n/a

Name

BDBM50105742

Synonyms:

4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl)-imidazol-1-yl]-cyclohexanol | CHEMBL97162 | trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole

Type

Small organic molecule

Emp. Form.

C20H21FN4O2

Mol. Mass.

368.4047

SMILES

COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1 |wU:16.18,wD:13.14,(3.13,-3.72,;3.16,-2.18,;4.5,-1.42,;4.53,.13,;5.87,.86,;7.2,.06,;7.17,-1.48,;5.82,-2.22,;8.5,-2.27,;8.7,-3.8,;10.21,-4.09,;10.93,-2.74,;9.88,-1.62,;10.17,-.1,;11.64,.4,;11.93,1.91,;10.77,2.91,;11.06,4.43,;9.31,2.4,;9.02,.89,;7.63,-4.91,;8.06,-6.39,;6.98,-7.48,;5.49,-7.1,;4.43,-8.22,;5.06,-5.63,;6.14,-4.53,)|

Structure