| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50105960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_207477 (CHEMBL815867) |
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| EC50 | 700±n/a nM |
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| Citation |  Duffy, KJ; Darcy, MG; Delorme, E; Dillon, SB; Eppley, DF; Erickson-Miller, C; Giampa, L; Hopson, CB; Huang, Y; Keenan, RM; Lamb, P; Leong, L; Liu, N; Miller, SG; Price, AT; Rosen, J; Shah, R; Shaw, TN; Smith, H; Stark, KC; Tian, SS; Tyree, C; Wiggall, KJ; Zhang, L; Luengo, JI Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem44:3730-45 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50105960 |
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| n/a |
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| Name | BDBM50105960 |
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| Synonyms: | 3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-m-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid | CHEMBL338398 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4O5S |
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| Mol. Mass. | 438.456 |
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| SMILES | Cc1[nH]n(-c2cccc(C)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:15.17| |
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| Structure | 
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