Reaction Details |
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Target | Thrombopoietin receptor |
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Ligand | BDBM50105975 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_207477 (CHEMBL815867) |
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EC50 | 3000±n/a nM |
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Citation | Duffy, KJ; Darcy, MG; Delorme, E; Dillon, SB; Eppley, DF; Erickson-Miller, C; Giampa, L; Hopson, CB; Huang, Y; Keenan, RM; Lamb, P; Leong, L; Liu, N; Miller, SG; Price, AT; Rosen, J; Shah, R; Shaw, TN; Smith, H; Stark, KC; Tian, SS; Tyree, C; Wiggall, KJ; Zhang, L; Luengo, JI Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem44:3730-45 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thrombopoietin receptor |
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Name: | Thrombopoietin receptor |
Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 71243.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_535587 |
Residue: | 635 |
Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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BDBM50105975 |
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n/a |
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Name | BDBM50105975 |
Synonyms: | 3-Hydroxy-4-{N'-[1-(4-methanesulfonyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid | CHEMBL338631 |
Type | Small organic molecule |
Emp. Form. | C21H18N4O7S2 |
Mol. Mass. | 502.52 |
SMILES | Cc1[nH]n(-c2ccc(cc2)S(C)(=O)=O)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:18.20| |
Structure |
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