| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50096557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_39503 |
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| IC50 | 30±n/a nM |
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| Citation |  Willoughby, CA; Berk, SC; Rosauer, KG; Degrado, S; Chapman, KT; Gould, SL; Springer, MS; Malkowitz, L; Schleif, WA; Hazuda, D; Miller, M; Kessler, J; Danzeisen, R; Holmes, K; Lineberger, J; Carella, A; Carver, G; Emini, EA Combinatorial synthesis of CCR5 antagonists. Bioorg Med Chem Lett11:3137-41 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50096557 |
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| n/a |
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| Name | BDBM50096557 |
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| Synonyms: | CHEMBL312701 | N-[(S)-2-(3-Chloro-phenyl)-4-(4-phenyl-piperidin-1-yl)-butyl]-N-methyl-benzenesulfonamide | N-[2-(3-Chloro-phenyl)-4-(4-phenyl-piperidin-1-yl)-butyl]-N-methyl-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33ClN2O2S |
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| Mol. Mass. | 497.092 |
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| SMILES | CN(C[C@@H](CCN1CCC(CC1)c1ccccc1)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 |
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| Structure | 
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