Reaction Details |
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Target | Microsomal triglyceride transfer protein large subunit |
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Ligand | BDBM50107794 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_103136 (CHEMBL712306) |
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IC50 | 410±n/a nM |
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Citation | Ksander, GM; deJesus, R; Yuan, A; Fink, C; Moskal, M; Carlson, E; Kukkola, P; Bilci, N; Wallace, E; Neubert, A; Feldman, D; Mogelesky, T; Poirier, K; Jeune, M; Steele, R; Wasvery, J; Stephan, Z; Cahill, E; Webb, R; Navarrete, A; Lee, W; Gibson, J; Alexander, N; Sharif, H; Hospattankar, A Diaminoindanes as microsomal triglyceride transfer protein inhibitors. J Med Chem44:4677-87 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Microsomal triglyceride transfer protein large subunit |
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Name: | Microsomal triglyceride transfer protein large subunit |
Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
Type: | PROTEIN |
Mol. Mass.: | 99365.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_971724 |
Residue: | 894 |
Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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BDBM50107794 |
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n/a |
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Name | BDBM50107794 |
Synonyms: | CHEMBL356937 | {5-[(4,4'-Bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester |
Type | Small organic molecule |
Emp. Form. | C26H20F6N2O3 |
Mol. Mass. | 522.439 |
SMILES | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(ccc3-c3ccc(cc3)C(F)(F)F)C(F)(F)F)cc2C1 |
Structure |
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