| Reaction Details |
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 | Report a problem with these data |
| Target | Microsomal triglyceride transfer protein large subunit |
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| Ligand | BDBM50107776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_103136 (CHEMBL712306) |
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| IC50 | 4800±n/a nM |
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| Citation |  Ksander, GM; deJesus, R; Yuan, A; Fink, C; Moskal, M; Carlson, E; Kukkola, P; Bilci, N; Wallace, E; Neubert, A; Feldman, D; Mogelesky, T; Poirier, K; Jeune, M; Steele, R; Wasvery, J; Stephan, Z; Cahill, E; Webb, R; Navarrete, A; Lee, W; Gibson, J; Alexander, N; Sharif, H; Hospattankar, A Diaminoindanes as microsomal triglyceride transfer protein inhibitors. J Med Chem44:4677-87 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Microsomal triglyceride transfer protein large subunit |
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| Name: | Microsomal triglyceride transfer protein large subunit |
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| Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99365.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_971724 |
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| Residue: | 894 |
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| Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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| BDBM50107776 |
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| n/a |
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| Name | BDBM50107776 |
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| Synonyms: | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-benzylamino-indan-5-yl)-amide | CHEMBL142519 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H25F3N2O |
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| Mol. Mass. | 486.5275 |
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| SMILES | FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2CC(Cc2c1)NCc1ccccc1 |
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| Structure | 
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