| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50549715 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2025623 (CHEMBL4679436) |
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| IC50 | 4.5±n/a nM |
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| Citation |  Kimura, H; Suda, H; Kassai, M; Endo, M; Deai, Y; Yahata, M; Miyajima, M; Isobe, Y N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors. Bioorg Med Chem Lett33:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_MOUSE | Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54550.12 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109577 |
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| Residue: | 479 |
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| Sequence: | MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSY
RGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLT
AVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKK
PRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMP
FEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
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| BDBM50549715 |
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| n/a |
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| Name | BDBM50549715 |
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| Synonyms: | CHEMBL4760680 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O2S |
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| Mol. Mass. | 368.453 |
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| SMILES | CN(C)c1ccccc1-c1ccc(NS(=O)(=O)c2ccc(C)cc2)nn1 |
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| Structure | 
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