| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX3X |
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| Ligand | BDBM50552037 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2033055 (CHEMBL4687213) |
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| IC50 | 1000±n/a nM |
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| Citation |  Brai, A; Riva, V; Saladini, F; Zamperini, C; Trivisani, CI; Garbelli, A; Pennisi, C; Giannini, A; Boccuto, A; Bugli, F; Martini, M; Sanguinetti, M; Zazzi, M; Dreassi, E; Botta, M; Maga, G DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins. Eur J Med Chem200:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DDX3X |
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| Name: | ATP-dependent RNA helicase DDX3X |
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| Synonyms: | DBX | DDX3 | DDX3X | DDX3X_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73247.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811954 |
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| Residue: | 662 |
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| Sequence: | MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
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| BDBM50552037 |
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| n/a |
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| Name | BDBM50552037 |
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| Synonyms: | CHEMBL4784714 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O2 |
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| Mol. Mass. | 351.4023 |
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| SMILES | COCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C)cc1 |
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| Structure | 
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