| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM50552534 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2035018 (CHEMBL4689176) |
|---|
| EC50 | 34±n/a nM |
|---|
| Citation |  Ruan, Z; Park, PK; Wei, D; Purandare, A; Wan, H; O'Malley, D; Stachura, S; Perez, H; Cavallaro, CL; Weigelt, CA; Sack, JS; Ruzanov, M; Khan, J; Gururajan, M; Wong, JJ; Huang, Y; Yarde, M; Li, Z; Chen, C; Sun, H; Borowski, V; Xie, JH; Anthony, M; Agler, M; Fink, BE; Harikrishnan, LS Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-?t (ROR?t) agonists. Bioorg Med Chem Lett35:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58133.31 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_103664 |
|---|
| Residue: | 516 |
|---|
| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
|
|
|
|---|
| BDBM50552534 |
|---|
| n/a |
|---|
| Name | BDBM50552534 |
|---|
| Synonyms: | CHEMBL4777230 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29Cl2N3O5S |
|---|
| Mol. Mass. | 530.464 |
|---|
| SMILES | COc1ccc(Oc2c(Cl)cc(NC(=O)CN3CCN(CC3)S(C)(=O)=O)cc2Cl)cc1C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
