| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A1 |
|---|
| Ligand | BDBM50458163 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2046079 (CHEMBL4700778) |
|---|
| IC50 | 1400±n/a nM |
|---|
| Citation |  Boy, KM; Guernon, JM; Zuev, DS; Xu, L; Zhang, Y; Shi, J; Marcin, LR; Higgins, MA; Wu, YJ; Krishnananthan, S; Li, J; Trehan, A; Smith, D; Toyn, JH; Meredith, JE; Burton, CR; Kimura, SR; Zvyaga, T; Zhuo, X; Lentz, KA; Grace, JE; Denton, R; Morrison, JS; Mathur, A; Albright, CF; Ahlijanian, MK; Olson, RE; Thompson, LA; Macor, JE Identification and Preclinical Evaluation of the Bicyclic Pyrimidine ?-Secretase Modulator BMS-932481. ACS Med Chem Lett10:312-317 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-glucuronosyltransferase 1A1 |
|---|
| Name: | UDP-glucuronosyltransferase 1A1 |
|---|
| Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59604.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22309 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
|
|
|
|---|
| BDBM50458163 |
|---|
| n/a |
|---|
| Name | BDBM50458163 |
|---|
| Synonyms: | CHEMBL4209316 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24FN7O |
|---|
| Mol. Mass. | 445.4921 |
|---|
| SMILES | CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2[C@@H](CCc12)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
