Reaction Details |
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Target | High affinity nerve growth factor receptor |
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Ligand | BDBM50554331 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2049097 (CHEMBL4703796) |
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Kd | 1.000000±n/a nM |
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Citation | Chen, L; Chen, Y; Zhang, C; Jiao, B; Liang, S; Tan, Q; Chai, H; Yu, W; Qian, Y; Yang, H; Yao, W; Yu, J; Luo, Y; Plewe, M; Wang, J; Han, XR; Liu, J Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem63:14562-14575 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity nerve growth factor receptor |
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Name: | High affinity nerve growth factor receptor |
Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
Type: | n/a |
Mol. Mass.: | 87498.18 |
Organism: | Homo sapiens (Human) |
Description: | P04629 |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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BDBM50554331 |
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n/a |
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Name | BDBM50554331 |
Synonyms: | CHEMBL4798635 |
Type | Small organic molecule |
Emp. Form. | C43H43FN10O6 |
Mol. Mass. | 814.8633 |
SMILES | Fc1cccc(c1)[C@H]1CCCN1c1ccc2ncc(-c3cccc(n3)N3CCN(CC3)C(=O)CCOCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)n2n1 |r| |
Structure |
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