| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM50115862 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_213307 |
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| Ki | 950.0±n/a nM |
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| Citation |  Mackman, RL; Hui, HC; Breitenbucher, JG; Katz, BA; Luong, C; Martelli, A; McGee, D; Radika, K; Sendzik, M; Spencer, JR; Sprengeler, PA; Tario, J; Verner, E; Wang, J 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg Med Chem Lett12:2019-22 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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| BDBM50115862 |
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| n/a |
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| Name | BDBM50115862 |
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| Synonyms: | 6-Chloro-2-(3-ethoxy-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine | CHEMBL62378 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15ClN4O2 |
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| Mol. Mass. | 330.769 |
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| SMILES | CCOc1cccc(-c2nc3cc(Cl)c(cc3[nH]2)C(N)=N)c1O |
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| Structure | 
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