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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tissue-type plasminogen activator | ||
| Ligand | BDBM50115875 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_208242 | ||
| Ki | 71000±n/a nM | ||
| Citation |  Mackman, RL; Hui, HC; Breitenbucher, JG; Katz, BA; Luong, C; Martelli, A; McGee, D; Radika, K; Sendzik, M; Spencer, JR; Sprengeler, PA; Tario, J; Verner, E; Wang, J 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg Med Chem Lett12:2019-22 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tissue-type plasminogen activator | |||
| Name: | Tissue-type plasminogen activator | ||
| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62931.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 562 | ||
| Sequence: |
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| BDBM50115875 | |||
| n/a | |||
| Name | BDBM50115875 | ||
| Synonyms: | 6-Fluoro-2-[2-hydroxy-3-(4-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine | CHEMBL62509 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23FN4O2 | ||
| Mol. Mass. | 382.4313 | ||
| SMILES | C[C@H]1CC[C@H](CC1)Oc1cccc(-c2nc3cc(F)c(cc3[nH]2)C(N)=N)c1O |wD:4.7,1.0,(9.17,-1.34,;7.63,-1.36,;6.84,-.03,;5.3,-.05,;4.56,-1.4,;5.34,-2.73,;6.87,-2.71,;3.02,-1.43,;2.22,-.1,;2.97,1.25,;2.17,2.57,;.63,2.54,;-.11,1.19,;-1.65,1.17,;-2.54,-.09,;-4.01,.37,;-5.32,-.44,;-6.66,.32,;-7.99,-.47,;-6.69,1.86,;-5.37,2.64,;-4.03,1.91,;-2.58,2.4,;-8.04,2.61,;-9.37,1.81,;-8.06,4.14,;.68,-.12,;-.07,-1.48,)| | ||
| Structure | 
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