| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50115874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208242 |
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| Ki | 35±n/a nM |
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| Citation |  Mackman, RL; Hui, HC; Breitenbucher, JG; Katz, BA; Luong, C; Martelli, A; McGee, D; Radika, K; Sendzik, M; Spencer, JR; Sprengeler, PA; Tario, J; Verner, E; Wang, J 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg Med Chem Lett12:2019-22 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50115874 |
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| n/a |
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| Name | BDBM50115874 |
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| Synonyms: | 2-(2-Hydroxy-3-phenoxy-phenyl)-1H-indole-5-carboxamidine | CHEMBL59704 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N3O2 |
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| Mol. Mass. | 343.3786 |
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| SMILES | NC(=N)c1ccc2[nH]c(cc2c1)-c1cccc(Oc2ccccc2)c1O |
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| Structure | 
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